Laboratory research demonstrates that 3DG is present in skin and causes: inflammation decreased production of collagen collagen and elastin cross-linking formation of Advanced Glycation End products (AGEs) oxidative stress and free radicals These all contribute to skin aging.
(3DG Accumulation in Aging Skin: Immunoflourescent Detection of 3DG-Modified Protein in Skin - Images Courtesy of Dr. Carol Artlett)