Supplamine® is a dual nutrient formula based on advanced scientific research. It is a combination of natural amino acids and a substitute sugar that does not cause toxic 3DG, oxidative stress, or free radicals. MEG21 is the only skin renewal products containing Supplamine®. Just as sugar substitutes beautify our figures, Supplamine® is a sugar substitute for beautifying skin. MEG21 with Supplamine® is gentle acting and free of acids and astringents.